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The evidence cited centered on four trials comparing high saturated fat intake against high intake of polyunsaturated fats with at least 2 years of sustained intervention, objective adherence measures, and validated cardiovascular event monitoring. Together, those trials showed a relative risk of 0.71 for coronary heart disease (95% CI 0.62-0.81).
Replacing saturated fat with refined carbohydrates and sugars doesn't have a benefit, other studies suggested.
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The GlobalData research group estimates that NASH could underpin a market worth more than $25 billion (22 billion euros) by 2026.
And the market should grow by a healthy 45 percent each year in the initial phases of the rollout of drugs to counter the disease, GlobalData says -- with the main customer base in the United States, western Europe and Japan.
Sarcopenia is loss of muscle mass due to aging. Post menopausal women should limit their alcohol intake. They should lift heavy things and do yoga, both of which have been shown to mitigate muscle loss and increase bone mass.
Led by Yu-Jin Kwon, MD, of Yonsei University College of Medicine in Seoul, prevalence of sarcopenia among post-menopausal women rose as alcohol-drinking patterns increased (7.6% low-risk, 11.0% intermediate-risk, 22.7% high-risk; P=0.003), published in Menopause, The Journal of The North American Menopause Society (NAMS).
In a fully adjusted model, postmenopausal women who consumed the highest levels of alcohol had over four-fold increased odds of developing sarcopenia compared to those who drank the least (OR 4.29, 95% CI 1.87-9.82). Similar findings were reported in an age-adjusted only model (OR 3.97, 95% CI 1.78-8.88).
Childhood obesity is associated with T2D but not T1D.
There is no single model for the artificial pancreas, which despite its name is not an actual artificial organ. To date, only one such device -- the MiniMed 670G from Medtronic -- has received approval from the FDA.
The 670G, which was approved last fall and is beginning to roll out to customers this spring, is described as a hybrid closed loop system.
I don’t imagine that this result is a surprise to many.
English children with obesity (≥95th percentile for age- and sex-specific BMI) had a significantly higher risk of incident type 2 diabetes compared with children within a normal BMI category (odds ratio 3.75, 95% CI, 3.07-4.57, P<0.01), reported Ali Abbasi, MD, PhD, of King's College London, and colleagues.
Similarly, obese children were at an over four times higher probability of developing type 2 diabetes versus normal weight children (4.33 incidence rate ratio, 95% CI, 3.68-5.08, P<0.01), they wrote in the Journal of the Endocrine Society.
I think this must be the second or third study to debunk Flegal. The bottom line is that a singly snapshot of BMI is not conclusive of anything.
Using data from three large cohort studies, comprising over 225,000 individuals, the researchers demonstrated that, no, there was no protective effect of being overweight. In fact, there was a small, but significant, added risk for all-cause mortality.
What did this study do that the 97 in that meta-analysis didn't? They looked at maximum weight achieved over the past 16 years in addition to current weight. This helps to account for those people that lost weight due to underlying, perhaps undiagnosed, diseases.