Basically anyone with a BMI of 30 or higher were treated and had a benefit. This bit is different, though:
The researchers predicted that about 20% of new diabetes cases could be prevented if adulthood weight was maintained within one body mass index (BMI) point (Population attributable fraction 21.9%, 95% CI, 15.8-27.6%), or within 3% of total weight (PAF 22.0%, 15.5, 28.0%).
On a population level, about 40% of new cases could be prevented through weight loss of 1.5±.5 BMI points (PAF 38.2%, 23.4-50.0%), or with a loss of 5±2% of body weight (42.4%, 24.3,5.1%), according to Adina L. Feldman, PhD, of the Medical Research Council (MRC) Epidemiology Unit at the University of Cambridge in the U.K., and colleagues, writing online in BMC Public Health.
So you only benefit if you’re obese— in other words, if you are carrying enough extra weight that your body can’t compensate. My hypothesis remains that the body compensates until it cannot. When it cannot, look out, because a cascade of issues arise.
However, the researchers reported that the benefits of weight maintenance and weight loss were not significantly associated with diabetes risk among normal weight individuals. Also, individuals who were age 30 at baseline did not experience the same relationship between incidence risk and BMI change among the BMI categories <25.0 and 25.0-29.9, except among those in the top category of 30.0-34.9 (ORs 1.11, 1.14, 1.08 per unit BMI change, respectively, for baseline categories).
The reviewing blogger is (or was) a nutrition professor.
Lustig says that when they are consumed in excess, they are metabolised (deaminated to be technical) in the liver, causing fat accumulation. This to me was mind blowing. In all the years I’ve spent in nutrition research, I had never associated branched chain amino acids (BCAA) with processed foods and never associated them with liver fat accumulation.
This article seemed pretty reasonable, until he got to what he actually eats, which is an incredibly high protein diet. There really is no need to eat 25-30% in protein. Compared to a typical or so-called standard American diet (SAD— get it?), it’s low fat at 25% or less, but yikes, 30% protein? No thank you. I should note here that I have no idea what my “macros” are because I don’t track or measure them. I’d be stunned though if my protein was ever that high a percentage of my intake.
Now the idea that food processing was an experiment that failed is absurd. Food processing took the wheat from flour to make bread, cakes, biscuits; it took grapes to make us wine and milk to make us butter, cheese and yogurt. It allowed us to preserve food through pickling or smoking or drying. And all of these are millennia old. Popcorn was used as a garland for young Aztec women in ceremonial dances. Pizzas were sold in Venice 800 years ago and every city in Europe had its unique patented sausage: Chorizo, Bratwurst, Biroldo, and Salami etc. Canned food came centuries ago and frozen foods a 100 years ago. High sugar foods such as cakes or biscuits were common in ancient Rome such as Cantuci or Savillum. Fundamentally, from the advent of fire, man has transformed the food chain to make it safer and tastier and modern times have done little to add to this except to make food cheaper and more available. I have argued this area at length in my recent book: “Ever seen a fat fox ~ Human obesity explored.”
All in all, this ‘Viewpoint’ would be failed if an undergraduate student were to present it, at least in my time. The editor of JAMA paediatrics should be ashamed of his or herself for gross negligence of the peer review process.
I’ve read this before, but I’ve seen little research evidence to show it (not saying it doesn’t exist, just that I haven’t seen any) and low carb shills deny it vehemently. This despite numerous anecdotes (especially from LC women) that it can be an issue.
Higher carbohydrate diets tend to be better for thyroid health, which is the master organ for regulating your metabolism. If you consistently under eat (stay in a deficit), and lower carbs, it’s been shown to down-regulate thyroid hormone production.
The fact that smoking increased the likelihood of opioids being prescribed mystifies me as well. Does nicotine affect pain perception?
Jarlenski's group examined data from 164,720 Medicaid-enrolled women in Pennsylvania who delivered a live-born infant vaginally from 2008 to 2013, and used ICD-9-CM codes to identify pain-inducing conditions: bilateral tubal ligation or anal sphincter tear, fourth-degree laceration or episiotomy. They noted that while they also assessed first and second-degree lacerations, periurethral trauma, laceration of the cervix, and high vaginal laceration, prevalence of opioid prescriptions did not differ by these diagnoses.